Fig. 2. Schematic representation of the Hippo pathway and its effects on the activation of TAP/TAZ. 'Hippo On' leads to the phosphorylation and inactivation of TAP/TAZ via LATS1/2, ultimately leading to the cytoplasmic retention of TAP/TAZ (left). 'Hippo Off' abrogates the TAP/TAZ inactivity, thus they are translocated into the nucleus to induce cell proliferation and tumor growth (right). P, phosphorylation; R, receptors; ↓, activation; x, block.